of Resveratrol on the Expression of MDR1 Gene in MOLT-4 Leukemic Cell Line

The multi-drug resistance phenomena can limit the effect of chemotherapy and lead to the recurrence of leukemia. One of the main mechanisms of multi drug resistance is the increased expression of MDR1 gene that codes P-gp، a transmembrane carrier that exports drugs out of the leukemic cells. The aim of this study was to explore the effect of resveratrol، a natural compound، on the expression of MDR1 gene in leukemic cell line MOLT-4.

MTT (Methyl Tiazol Tetrazolium) assay was used to determine the subtoxic doses of resveratrol for treatment of leukemic cells line real Time PCR was used to determine the expression of MDR1 gene. MOLT-4 cell line resistance was assessed after MTT implementation.

Resveratrol could not suppress the growth of MOLT-4 cells. Genetic studies revealed increased expression of MDR1 gene. Resistance of MOLT-4 cells to vincristine was increased after coadministration of vincristine and resveratrol.

we did not find evidence that resveratrol can reverse multi drug resistance in MOLT-4 cells.