Status Based on Biomarkers in Hemodialysis Patients

Kidney Disease has been known to be associated with bone abnormalities as early as 1883. Despite of the emergence of new and more inclusive terms; low turnover and high turnover definition still are useful definitions. Aluminum toxicity also is a great threat among these patients.

The study was started on 30 patients recruited from several hemodialysis (HD) units in Tabriz. Six patients left the study and only 24 patients completed their work up (10 female and 14 males) Immunoradiometric assay was used to measure the bone specific alkaline phosphatase (BAP) and intact parathyroid hormone (i PTH). Serum Aluminum was studied by atomic absorption

In 8 patients (8/24، 33%) serum level of iPTH was lower than 150pg/ml، and in 14 patients (14/24، 58%) serum BAP levels was lower than 27 U/L، but only in 5 patients (5/24، 20%) the combination of low iPTH (<150 ng/ml) and low BAP (<27 U/L) was present. serum aluminum of lower than <60 ng/ml is considered normal in HD patients. We had 21 patients (21/24، 87%) with serum Aluminum level above this defined limit.

This preliminary study at first revealed us the probable percentage of 20% for low turnover bone disease among our patients. Secondly and more importantly disclosed the high rate of aluminum exposure in our dialysis population.