Influence of Formulation Variables of Nanostructured Lipid Carriers on Their Physicochemical and Drug Release Properties

Oral administration of insulin is an interesting route due to the fact that it is more comfortable, and because of intestinal absorption, portal drainage of insulin to liver is more physiologic than subcutaneous injection. This study evaluates the efficacy of three types of SPH polymer-based oral insulin capsules on blood glucose in patients with type I diabetes. The highest bioavailability obtained in our study was for 800 IU core outside insulin capsules in patient #2 that was calculated 1.13%. Patients that had more good response; were younger, and have shorter duration of diabetes but they have light weight and are sensitive to insulin, but patients that were resistant had long duration of diabetes and were older age.