Current urbanization and settlement trends have adverse psycho-physical impact on the safety، health and well-being of the city dwellers. Crime، lack of community، lack of physical activity and dependence on motorized transportation serve as examples of urban ills. Sustainable design strategies in urban neighborhoods and open spaces can have significant contribution to human physical health and psychological well-being. The sustainable urban design agenda and design criteria such as green and quality open spaces، pedestrian areas، creating dense neighborhoods with mix land uses and infill development projects in derelict and lost spaces، decreasing dependence on motorized transport with public services such as community schools and developing local public transport are of the main strategies that can addressed the various health and well-being contributions of different urban habitats.