Effects of hydro-alcoholic extract of Eriobotrya japonica Lindl. flowers on CDNF, SOD and MDA levels of cerebral cortex in experimental model of Parkinson's disease in rat

The flowers of Eriobotrya japonica Lindl. have antioxidant and protective effects. The aim of this study was to investigate the effects of neuroprotection with hydro-alcoholic extract of Eriobotrya japonica flowerson CDNF، malondialdehyde and superoxide dismutase levels in the rat cerebral cortex in an experimental model of Parkinson''s disease. In this study، animals were randomly divided into three groups of nine each (control، damaged and damaged treated with plant extract). At first، the second and third groups of rats received the solvent of extract (saline) and the extract (200 mg/kg body weight) intraperitoneally for twelve weeks and three days per week، respectively. For Parkinson''s disease in rats، 6-OHDA was injected into the right ventricle of the brain after 12 weeks. After five days، rats were sacrificed and CDNF، SOD and MDA levels in their cortex were measured. Data were analyzed using ANOVA test. Our results showed that pre-treatment with the flower extract of Eriobotrya japonica، increased CDNF and SOD and decreased MDA levels of cerebral cortex. These effects may be caused by phenolic and flavonoid compounds of this plant with strong antioxidant properties. Therefore، it could be concluded that this plant extract has protective role against Parkinson''s disease because of protecting neurons against oxidative damage of toxic 6-OHDA.