Hepatotoxicity in sheep and goats caused by experimental feeding with foxtail millet (Setaria italica)
Message:
Abstract:
Background
Some species of grass cause poisoning and hepatogenous photosensitization in animals.
Objectives
Feeding trials were conducted in sheep and goats to evaluate the hepatotoxic effects of Setaria italica (S. italica).
Methods
Twelve indigenous male sheep and goats were used in this study. The animals were kept outdoors against prevailing climatic conditions. They were fed with S. italica freely for 50 days. Some biochemical factors associated with liver function, such as total bilirubin (TBIL), direct bilirubin (BC), aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyltransferase (GGT) activities, blood urea nitrogen (BUN), total protein (TP), and albumin (ALB), were measured on day 0, 7, 14, 21, 28, 35, 42, and 49 of the experiment. On the 50th day, the animals were sacrificed and necropsied, then the gall bladder and livers were removed for pathological study. Blood samples on day 0 (prior to feeding with S. italica) were set as the control group.
Results
Three sheep and 3 goats showed signs of intoxication, including facial edema, mucus hyperemia, runny nose, lacrimation, and icterus. Post-mortem examination revealed varying degrees of generalized icterus, degeneration, necrosis and cell swelling of hepatocytes, formation of acidophilic bodies, and mild hyperplasia in biliary ducts.
Conclusions
Clinical signs, laboratory findings, and necropsy findings, support the potential of S. italica in the induction of hepatotoxicity and secondary photosensitivity in sheep and goats.
Language:
English
Published:
Iranian Journal of Veterinary Medicine, Volume:9 Issue: 2, Spring 2015
Pages:
79 to 86
magiran.com/p1419601  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!