The Effect of 8 Weeks of High Intensity Interval Training on Mir-29 Gene Family Expression and Cardiac Hypertrophy of Healthy Male Rats
Message:
Abstract:
Background And Objective

In this study the effect of high intensity interval training on miR-29 expression that is expressed in the heart and in the regulation of physiological processes, including extracellular matrix and cardiac hypertrophy of healthy male rats were examined.

Materials And Methods

16 Wistar rats were divided into training (n=8) and control (n=8) groups. After one week of familiarization, the training protocol was performed for 8 weeks. The progressive training protocol included 6 min warm up (with 50 to 60% of VO2max), 7 frequency (4 min with 80 to 90% of VO2max and 3 min with 50 to 60% of VO2max) and 5 min cool down with 50 to 60% of VO2max. The animals were sacrificed 24 hours after the last session of training program and cardiac samples were kept at a temperature of - 80 ° C and the variable expression levels (miR-29a، miR-29b and miR-29c) were measured by RT-PCR method. Analysis of the results was performed by independent t-test.

Results

Training led to a significant increase in miR-29a (3. 5 fold), miR-29b (2. 24 fold) and miR-29c (9. 77 fold) gene expression in the training group compared with the control group (p<0. 001). Also training brought about 22% increase in heart weight to body weight ratio (HW/BW) in the training group (p<0. 001).

Conclusion

These results point out that training increases miR-29 expression which is associated with physiological cardiac hypertrophy and improved heart performance.

Language:
Persian
Published:
Journal of Advances in Medical and Biomedical Research, Volume:23 Issue: 99, 2015
Pages:
14 to 24
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