Evaluation the Effect of Periodental Supplement on Prevention of Gastrointestinal Infection of Helicobacter Pylori

The oral cavity has been proposed as a reservoir for Helicobacter, pylori(H. pylori) that could be responsible for the refractoriness of gastric infection to triple therapy. The data on the role of dental plaque in the transmission of Helicobacter pylori have varied. Furthermore, there has been few reports on the relationship between dental plaque control and H. pylori infection of gastric mucosa. This study evaluated the efficiency of periodontal treatment as a supplement of triple therapy vs. triple therapy alone, in gastric H. pylori eradication. In this single blind, randomized clinical trial, fifty patients were selected randomly into two intervention and control groups, each group contained 25 patients. The Urea Breath Test(UBT) was conducted on total subjects in a period of 8-12 months after triple therapy for both groups and periodontal treatment for intervention group. Poisson regression model and IRR was used in order to find a significant relationship between the two groups. Our results indicated that 80 % of those treated with the combined therapy exhibited successful eradication of gastric H. pylori, compared with 56 % who underwent only triple therapy; however; there was not a significant difference between the two groups(P value=0.167). The adjunction of periodontal treatment to eradication therapy appeared not to reduce gastric H. pylori recurrence compared with eradication therapy alone among patients with gastric diseases associated with H. pylori. It seemed, there was not enough evidence in this field, Therefore, there is a need for to further clinical trials.