Comparison of FGF21 level in type 2 diabetic patients with healthy subjects and correlation of its with metabolic syndrome components

to have a potent antidiabetic effect in animal models. In human studies activity of this factor is associated with development of metabolic syndrome. The aim of this study was to compare the concentration of this factor in type 2 diabetic patients and healthysubjects and also relation of this factor with metabolic syndrome componentswas investigated.

30 type 2 diabetic patients and 40 healthy subjects were enrolled in this study. Demographic data of patients were recorded. HbA1c، FBS، lipid profiles، insulin level،liver enzymes and FGF21 were measured for all subjects. Insulin resistance was calculated by homeostatic model assessment of insulin resistance (HOMA-IR) formula. FGF21 level was compared between diabetic patients with healthy control group and also relation of this factor was determined with metabolic syndrome components.

Difference of FGF21 level was not significant between type 2 diabetic patients and healthy subjects. There were not significant correlation between FGF21 level and metabolic syndrome components. FGF21 was positively associated with SGPT level.

It seems that FGF21 is not related to metabolic syndrome components in Iranian population، but this observation remains to be determined by large clinical studies.