EfFECT OF PROGRESSIVE AEROBIC EXERCISE TRAINING ON PLASMA KALLIKREIN-7 CONCENTRATION AND INSULIN RESISTANCE INDEX IN WOMEN WITH NORMAL WEIGHT AND OVERWEIGHT

kallikrein 7 (KLK7)، a serine protease with a chymotrypsin-like specificity، is able to cleave human insulin in the A- and B-chain. The aim of this study was to investigate the effects of aerobic exercise training on plasma KLK7 concentration and insulin resistance index (HOMA-IR) in normal and overweight sedentary women. Twenty-eight sedentary women، aged 24-60 years، voluntary participated in this study and according to body mass index status divided into normal (n=15) and overweight (n=13) groups. All subjects completed an 8-week progressive aerobic exercise training program (running with 40- 80% Heart rate reserve). Metabolic and Anthropometric (body weight، BMI، body fat percentage) parameters in addition to plasma KLK7 concentrations were measured at baseline and end of training program. Body fat percentage significantly decreased (P<0. 05) and maximum oxygen consumption increased (P<0. 05) by this training program in both training groups. At baseline، plasma KLK7 concentration in overweight women was significantly higher compared with normal weight group (P<0. 05). Plasma KLK7 concentrations significantly increased after 8-week aerobic exercise training only in normal weight group (P<0. 05). Changes in plasma KLK7 concentrations were not correlated with changes in insulin concentration and insulin resistance index (P<0. 05). Aerobic exercise training could be an effective factor to increase plasma KLK7 concentration in sedentary women. These data do not support a role of plasma KLK7 in insulin resistance alterations.