Study on antibacterial effect of new Thiazole and Imidazoline derivatives on Zoonosis bacterial pathogen (Rhodoccocus equi, Brucella abortus and Pasteurella multocida)

Drug resistant in bacterial pathogen is a danger that of it ability and prosperity of live stock industry and this problem causes detection and using from new antibacterial compound are essential. Thiazole and imidazole derivatives are new antibacterial compound that in this study have examined antibacterial effect of these derivatives on Rhodoccocus equi, Brucella abortus and Pasteurella multocida. for investigation and comparative antibacterial effect, Disk diffusion was used for the calculation of growth inhibition zone diameters and serial dilution method in microplates was used to assess growth inhibitory concentrations (MICs). results showed all of Thiazole derivatives didn’t have any inhibitory effect on Brucella abortus, also imidazoline derivatives didn’t have inhibition on any bacterial too. Inhibitory effect just showed from thiazole derivative whit MIC 250 and 31.25 μg/ml on R. equi and P. multocida, respectively. inhibitory impact of thiazole derivatives on R. equi and P. multocida was proved that this effect is very stronger on P. multocida.