Comparison of promethazine and morphine to control pain of appendectomy surgery: A randomized clinical trial

Pain after appendectomy surgery is the most common patient's dissatisfaction which the easiest method of treatment is opioids. Side effects of them led to using more appropriate medications instead of opioids to relieve the pain. Aim of This study was to compare the pain relief effects of morphine and promethazine in patients with appendectomy. This triple blind clinical trial was carried out on 60 patients in 49 -15 years old undergoing appendectomy in Shahid Beheshti Hospital in Sabzevar, Iran, 1391.Participants were selected using by convenience method and then randomly divided into two groups of 30 ones. The control and intervention group was injected narcotic and promethazine, respectively. The level of pain was investigated according to the standard numeric pain scale, in the first hour after treatment. Data was analyzed using the Pearson and chi-square test by means of SPSS version 18 in the level of significance of 0.05. there was observed a significant difference between two groups in the level of postoperative pain relief, (P = 0/000), so that the level of pain after injection of promethazine 3/30 ± (1/33) was less than morphine 6/07± (1/23). Also, this difference was significant in half an hour after surgery (p = 0/000) with mean score of 3/69 ± (1/33) and 6/74± (1/30) for Promethazine and morphine, respectively. According to these results, basic planning to use phenothiszines such as promethazine instead of opioids is suggested.