Topical Effects of Aloevera and Propolis on Open Wound Healing in Male Rats
Abstract:
Introduction
Traditionally, the natural ingredients have been used for faster healing of wounds. In this study, the effects of topical application of propolis and aloe vera were studied on the healing of open skin wounds in male rats.Materials and Methods
32 male Wistar rats (300 - 350 g) were randomly divided into control and 3 experimental groups. After anesthesia, under sterile conditions round full-thickness wound with a diameter of 2.5 cm were created above the thigh of animals. In experimental groups, treatment of wound was performed with usage of ointment containing approximately 1gram of propolis or aloe vera or both of them, two times per day and continued for 20 days. During this period, the rate of wound healing was assessed by measuring the levels of wound in all groups. Also at the last day, under deep anesthesia, 1 mL of urine samples were taken from the bladder of all animals and its hydroxyproline concentration were measured. Data were analyzed using SPSS software with ANOVA and Dunnett test.Findings
Wound healing percentage showed no significant difference between control and experimental groups on 2 to 9 days, but in the 10 to 20 days interval, the treatment groups showed significant differences compared to control(P<0.05). The hydroxyproline content significantly increased in the combined aloe vera and propolis group compared to control (P<0.01).Discussion & Conclusion
The topical use of aloe vera or propolis accelerates healing of full thickness skin wounds and their combination is more effective.Keywords:
Wound healing , Aloevera , Propolis , Rat
Language:
Persian
Published:
Ilam University of Medical Science, Volume:23 Issue: 4, 2015
Pages:
32 to 40
magiran.com/p1465915
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!