Comparison of Higher-order Aberrations after Personalized Treatment versus Personalized Treatment Advanced Photorefractive Keratectomy for Myopia and Myopic Astigmatism

The aim of this study was to compare higher-order aberrations between personalized treatment (PT) versus personalized treatment advanced (PTA) photorefractive keratectomy (PRK) for myopia and myopic astigmatism. In this clinical trial, 80 eyes of 40 patients who met inclusion criteria were enrolled. They underwent PRK using PT or PTA algorithm randomly. Higher-order aberrations were measured and compared between the study groups pre-operatively and at months 3 and 6 postoperatively. The two study groups were comparable in terms of preoperative higher-order aberrations. Compared to the preoperative values, higher-order aberrations were significantly increased in the PT group (p<0.001), but decreased in the PTA group (p<0.001). Spherical aberration exhibited a significant increase postoperatively in the PT group (p<0.001) but remained unchanged in the PTA group (P=0.57). PRK using PT algorithm resulted in an increase higher-order aberrations. PTA algorithm provided better results in terms of postoperative higher-order aberrations and could treat pre-existing higher-order aberrations.