Association of Serum 25-hydroxyvitamin D concentration and Markers of Metabolic Syndrome in adult women

Some cross sectional studies have showed association of vitamin D deficiency with components of metabolic syndrome. But findings are inconsistent. With regarding to high prevalence of vitamin D deficiency in Iran this study was designed. In this cross sectional study, 156 women aged ≥30 with at least three of five criteria metabolic syndrome were recruited by consecutive random sampling. Serum 25(OH) D levels and components of the metabolic syndrome were measured. Metabolic syndrome was defined according to NCEP/ATP III criteria. Subjects were three groups according to their serum concentration of 25(OH)D. Mean of serum concentration of 25-hydroxyvitamin D was 20.5 ± 10.8 ng/ml, and %54.5 of subjects were vitamin D deficient, 23.1% and 22.4% were insufficient and sufficient, respectively. After adjustment for age, BMI, physical activity, ANCOVA showed fasting blood sugar concentration was inversely associated with serum 25(OH)D(P=0.004), at the other hand HDL-C had significant correlation across different groups of vitamin D status (P=0.014). Waist Circumference had favorable changes, although there was no statistically significant correlation. No significant association was observed between other metabolic syndromes of components across 25(OH) D groups. In study, association serum 25(OH) D with fasting blood sugar and HDL-C concentrations can predictive it relation with chronic disease. But, determining role of vitamin D with metabolic syndrome and related disease, large prospective studies and clinical trial is necessary to be conducted.