Relationship of Body Mass Index with Failure Rate in Assisted Reproductive Techniques in Polycystic Ovary Syndrome Infertile Women; A Retrospective Cohort Study

Polycystic ovary syndrome (PCOS) is common in people seeking assisted reproductive techniques and the prevalence of obesity in these women is 50%. Body mass index can be effective in the result of IVF treatment cycle. This study was performed with aim to determine the relationship between body mass index and chemical pregnancy after IVF treatment cycle or intracytoplasmic sperm injection in infertile women with polycystic ovary syndrome at Royan Institute.

In this retrospective cohort study, 983 treatment cycles of IVF/ICSI related to infertile couples referred to Royan institute during 2012-2013 were assessed. A total of 115 cases diagnosed with polycystic ovary syndrome were entered to the study. Body mass index was determined by measuring height and weight. After receiving proper treatment cycle, chemical pregnancy rate were compared between overweight and obese women with normal women. Data analysis was performed using Stata software (version 13). P

Among 983 treatment cycles, 11.7% of patients were diagnosed with polycystic ovary syndrome. In these cases, after adjusting for confounding variables and compared to the women with normal body mass index, the risk of treatment failure in overweight patients was 1.04 times (95% CI: 0.58-1.87, P=0.883) and in obese patients 0.98 times (95% CI: 0.51-1.86, p=0.961).

In women with PCOS, the rate of pregnancy after assisted reproductive treatment was not significantly different between normal, overweight and obese cases.