The expression of miR-206 in response to one session resistance exercise in fast and slow twitch skeletal muscles of Wistar male rats

MicroRNAs are non-coding RNAs that are involved in post-transcriptional down regulation of genes and myogenesis. The purpose of this study was to investigate the effects of an acute bout of exhaustive resistance exercise on miR-206 expression in slow and fast twitch skeletal muscles in trained and untrained male wistar rats. This experimental study was conducted with the animal model. 30 male wistar rats, were assigned in three groups: control (n=6), traind (n=12) and untrained (n=12). 48 h after the last training session in trained group(Resistance training included weight lifting up on a vertical ladder for 8 weeks), trained and untrained groups performed an acute exhaustive bout of resistance exercise and were sacrificed in a 4 time zone. Expression of miR-206 was measured by Real time – PCR technique. The differences between variables were determined by one way ANOVA method. statistical analysis by one-way ANOVA showed that between trained and untrained groups in FHL and Sol muscles there was a significant difference (p=0.05) statistically. Also in both groups expression of miR-206 in FHL muscle elevated and in Sol muscle decreased. The findings showed that response of miR-206 to one bout resistance exercise with and without adaptation to training in fast and slow muscles is different.