The Effect Of Eight Week Continuous Training On Expression Of Mir29mRNA, In Healthy Male Rat's Cardiac Muscle

The purpose of this study was to evaluate the effect of eight weeks continues training on the expression of miR29mRNA in the cardiac muscle of healthy male rats. Male Wistar rats (n=6/group) were randomly divided into two groups: sedentary and training group. Training was prescribed 70-75% vo2max for 30 min, 5days/week. Hearts were isolated 24 hours after the last session. Using quantitave RT-PCR, miR29 expression changes were analyzed then calculated by 2ΔΔСТ method. To determine the significance of variables between study groups, independent t-test was used. Results showed that there is a significant increase, in gene expression miR29a,c in training group compared to control group (P=0.001).But miR29b gene expression were significantly reduced (P=0.416). Based on the study findings, continuous endurance training induce physiological hypertrophy training is at the heart of the group and lead to a significant increase in expression levels miR29a,c. Since this increase leading to a significant reduction in expression of collagen isoforms, it can be concluded that rising miR29a,c in physiological hypertrophy induced by endurance training is directly regulates extracellular matrix and ventricular compliance.