Study of the effect of Syzygium aromaticum and Rheum officinale extract gel on skin wound healing in rat.

In the present study efficacy of Eugenia caryophilla and Rheum officinale extract have been investigated on the wound healing. Forty Wistar rats, weighting 200-250 g, were taken for this study. A full thickness wound in 1 cm length was created on the paravertebral region of each animal. Then animals were divided to experiment (n=20) and control groups (n=20), randomly. Wounds of animals in experiment group were treated with combined Eugenia caryophilla and Rheum officinale extracts twice a day for 3 days. On days 3, 7, 10 and 14, after assessment of wound contraction rate, 5 rats of each group were euthanized and tissue samples were obtained for histopathologic examination. In this study wound contraction was more evident in experiment group than control group in all days, however there was no significant difference between them (p