Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents
Author(s):
Abstract:
Objective(s)
Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials And Methods
Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out.Results
Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion
This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didnt follow the ficks law. The water uptake and dissolution (DS), increased with the passing of time. Keywords:
Language:
English
Published:
Iranian Journal of Basic Medical Sciences, Volume:19 Issue: 3, Mar 2016
Pages:
330 to 336
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