Relationship between β-globin gene mutations and blood factors in Beta- Thalassemia carriers

Iran, located in Eastern Mediterranean region, is one of the noteworthy centers for the prevalence of Beta-Thalassemia genetic disorder. The aim of this study was to investigate the relationship between Beta-globin gene mutations and blood factors in the carriers of Beta-Thalassemia.
This descriptive study was to investigate the relationship between beta-globin gene mutations and the average volume of red blood cells in Beta-Thalassemia carriers referred to the health network. The study was conducted in Pakdasht and Varamin from 1997 to 2013. Ethical issues such as confidentiality of studied community were all considered.
In the present study, the relationship between some blood parameters of red blood cells, such as the mean volume of red blood cells (MCV), and the type of mutation in the beta-globin was analyzed. MCV was statistically related to the type of mutation (p=0.05). The mean and standard deviation values of MCV were 62.1 and 3.9, respectively.
The amount of MCV can be used as a guide for quick access to genetic mutations in Beta-Thalassemia carrier couples referred to Genetic centers before and during the pregnancy.