Comparing the effect of Tranexamic acid and Dexmedetomidine on bleeding during Rhinoplasty
Author(s):
Abstract:
Aims and
Findings: The amount of intra-operative bleeding was 145.2±22.1 ml in DEX group and 141.8±24.1 ml in TXA group (p=0.46). The mean score of surgeons satisfaction was 1.65±0.53 in DEX group and 1.42±0.64 in TXA group (p=0.089).
Background
Bleeding during rhinoplasty is a complication that decreases the surgeons vision and even causes more side effects. Different methods have been proposed to reduce bleeding during otorhinolaryngology surgeries. The aim of this study is to compare the effect of tranexamic acid (TXA) and Dexmedetomidine (DEX) on the amount of bleeding in patients candidate for rhinoplasty. Materials And Methods
In this randomized double-blind clinical trial, 76 patients who were candidate for elective rhinoplasty surgery entered the study. The first group received 10 mg/kg Tranexamic acid (TXA), and the second group received 1 μg/kg Dexmedetomidine (DEX) intravenously within 15 minutes immediately after induction. Bleeding volume, hemodynamic parameters and surgeons satisfaction were evaluated. Findings: The amount of intra-operative bleeding was 145.2±22.1 ml in DEX group and 141.8±24.1 ml in TXA group (p=0.46). The mean score of surgeons satisfaction was 1.65±0.53 in DEX group and 1.42±0.64 in TXA group (p=0.089).
Conclusions
Totally the efficacy of DEX and TXA was equal. TXA reduces bleeding in major surgeries but for rhinoplasty, in which bleeding volume is not so much perhaps using DEX is a better option.Keywords:
Language:
Persian
Published:
Journal of Anesthesiology and Pain, Volume:7 Issue: 1, 2016
Pages:
36 to 43
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