Cinnamon(Cinnamomum zeylanicum) hydroalcoholic extract effects on histological structure of hippocampus in ovariectomized mice
Author(s):
Abstract:
Background And Objective
Hippocampus is a part of limbic system and has an important role in memory and learning. Menopause causes failure in the memory and learning in women. Different medicines have been used to improve memory in menopausal women. Nowadays, Herbal medicines due to their fewer side effects are used in treatment of various diseases. Cinnamon is one of these herbal medicines that claimed to improve sexual potential and memory. The aim of the present study was to evaluate Cinnamon hydroalcoholic extract effect on hippocampal histology following ovariectomy (experimental menopause).Subjects and
Methods
17 adult female mice(30±5g) were divided into 3 groups as control, sham(ovariectomized) and treatment. Cinnamon hydroalcoholic extract(200mg/kg) was administrated every other day for 20 days IP. 24 hours after last administration, animals were euthanized, their brain were isolated immediately and were floated in fixative solution. Tissue sections of brain were prepared and stained by Hematoxylin-Eosin(H&E) and studied by light microscopy.Results
Ovariectomy increased degenerated cells in CA1 and DG regions of hippocampus significantly(PConclusion
Cinnamon decreased histological changes following ovariectomy (experimental menopause) in mice hippocampus and it may be a suitable medicine to improve memory and learning in menopausal women.Keywords:
Ovariectomy , Histology , Cinnamon , Hippocampus , Mice
Language:
Persian
Published:
Jundishapur Scientific Medical Journal, Volume:15 Issue: 1, 2016
Page:
73
magiran.com/p1520931
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