The Role of Aerobic Exercise on Pain By Histamine Receptors Using Formalin Test in Mice

Aerobic exercise or cardio is defined as a physical exercise that causes high oxygen consumption compared to the rest and conducted to increased cardiorespiratory intensity. Different substances, can inhibit pain occurred through opioids, histaminergic, and cholinergic receptors. This study was done to determine the role of aerobic exercise in pain by histamine receptors using formalin test in mice.
In this experimental study, by use of formalin test, the analgesic effect has been used in three groups of control, test one and test two and by ranitidine which is a histamine receptores inhibitor, the analgesic effect of aerobic exercise and the role of histamine receptors were investigated. For this purpose by use of mean score of pain and two way Anova and repeated major in every 5 minute; regarding, formalin test, as a standard pain inducing, was used.
Our result indicated that subcoutanous injection of formalin to the paw of the animal significantly(P The analgesic effects of aerobic exercise may be induced by histamine receptors.