Protective effect of broccoli sprouts powder against metabolic fructose-induced metabolic disorders in rats

In this study, we aimed to investigate whether a diet rich in high-sulforaphane broccoli sprouts powder (BSP) could attenuate metabolic abnormalities induced by high-fructose corn syrup (HFCS).
Forty-eight male wistar rats with similar average body weight (253±23g) were randomly allocated into four groups: Baseline control, control (C) (normal diet), fructose (F) (normal diet water containing 30% fructose), and fructose BSP (F) (diet with 5% BSP water containing 30% fructose), and followed for 8 weeks. Biochemical measurements including fasting serum triglyceride levels, total cholesterol, HDL-C, alkaline phosphatase, gamma-glutamyl transferase, alanine aminotransferase, and aspartate aminotransferase were assessed at baseline, and the fourth and eighth weeks.
The mean change of body weight was 31.5%, 31.4% and 18.3% in the C, F, and F groups, respectively; the mean weight gain of group F was lower than those of the other groups (p=0.009). A significant increasing trend was observed in serum total cholesterol, triglycerides and LDL-C levels in group F during the intervention (p‍ High-sulforaphane broccoli sprouts could have favorable effects against metabolic disorders-induced by a high fructose diet.