Evaluating Baremoom Mouthwash Efficacy in Treatment of Chemotherapy-Induced Mucositis
Author(s):
Abstract:
Introduction
Chemotherapy-induced oral mucositis is regarded as a painful and discomforting chemotherapy complication , affecting patients quality of life and endurance to continue the treatment. Hence, treatment of mucositis is of great significance. The present study was conducted to evaluate the effect of Baremoom mouthwash in treatment of chemotherapy-induced mucositis .Methods
This interventional double-blinded randomized clinical trial study was performed on 40 adult patients under chemotherapy in blood and oncology department of Shahid Sadouqhi hospital. The total of 40 patients were randomly divided into two groups: an experimental baremoom group and a control placebo group each containing 20 subjects. Baremoom mouthwash (30% extract, Soren Tektoos, Mashhad) and placebo mouthwash ( Sterile water with allowable additives ,Soren Tektoos, Mashhad ) with same apparent properties were given to the patients (3 times a day) for 7 days after mucositis detection. The patients were evaluated in regard with mucositis grade (0-4 WHO) and wounds extension on 1th , 3th and 7th days after the study begining. In order to statistically analyze the collected data, Freidman, MannWhitney, and wilcoxon W tests were applied utilizing SPSS software (ver, 17).Results
On 3rd and 7th days, mean degree of wound extension and mucositis were demonstrated to be significantly different between the two groups. According to Friedman test, both experimental and control groups revealed a significant difference in regard with wound extension and mucositis grade within the three time periods.Conclusion
The study findings indicated that Baremoom mouthwash was more effective in chemotherapy- induced mucositis than placebo. Hence, this agent can be recommended as an appropriate medicine in order to eliminate mucositis symtoms and decrease oral ulcers.Keywords:
Language:
Persian
Published:
Journal of Shaeed Sdoughi University of Medical Sciences Yazd, Volume:23 Issue: 12, 2016
Pages:
1220 to 1232
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