Comparative effects of Omeprazole and Captopril on Cysteamine induced duodenal ulcer on Rat

Cysteamine is known to induce duodenal ulcer by oxidative effect in mucus. We studied the protective effect of captopril (with doses 15, 30 and 45mg/kg respectively at0.5 and 12h before ulcer induction) and omeprazol (withdoses 10, 20 and 30mg/kg respectively at 0.5 and 12h before ulcer induction) against cysteamine–inducedduodenal ulcer (450mg/kg twice at 4h interval) in 112 rats by determining duodenal ulcer Index and ulcer inhibition percent. Drugs used in this study were given by gavages. Twenty-four hours after the final dose of normal saline or cysteamine, the animals were killed under ether anesthesia and the duodena were excised carefully. Each duodenum was cut open along the antimesentric side and rinsed with saline and examined under 5-fold binocular magnification. For histological examination, tissue samples were fixed in 10% neutral buffered formalin. We found that Captopril and Omeprazole decreased the incidence of ulcers and also enhanced the healing of ulcers. Ulcer Index by Cysteaminewas 3.02 ±0.6 but after the administration of Omeprazol decreased to 0.94±0.24 and with Captopril reached to 0.7 ±0.24 that both was significant (P≤0.05). Percent of ulcer inhibition by Omeprazol %68.74±8.24 and by Captopril administration were %77.6± 8.24. Conclusively, both drugs have anti ulcer effects that are probably due to antioxidant effects of these drugs.