Study the relationship between vitamin D levels and the amount of IgE in adults with allergic disease in Tehran

Vitamin D deficiency is a common problem of the world that has many complications, especially in adults. Studies suggest a relationship between low levels of vitamin D and allergic diseases. Regarding to the role of vitamin D in the regulation of immune system, Vitamin D deficiency can be one of the effective factors in the development and exacerbation of allergic diseases. Hence, the present study was aimed to examine the relationship between vitamin D levels and the amount of IgE in adults with allergies (type 1) in Tehran.
In a cross-sectional study, 80 people with allergies (28 males and 52 females) older than 16 years old referred to the Khorshid Allergy and immunology Clinic were evaluated. Vitamin D and total IgE levels were determined by ELISA. Three levels of vitamin D deficiency (less than 20 ng/ml), insufficient (30-20 ng/ml) and sufficient (more 30 than ng/ml) were classified. In order to confirm the presence of specific IgE, skin prick test was used. Finally, the data were analyzed by SPSS software version 20.
The mean level of vitamin D in the all subjects was 21.59 ng/ml that fall into insufficient range (less than 30 ng/ml). Based on the results, the abnormal level of vitamin D was present in 76.25% (65% insufficient and 11.25% deficient) and only 23.75% of them had sufficient vitamin D levels. The results also showed abnormal level of vitamin D in women was more than men (67.21% to 32.78%). In addition, vitamin D deficiency was significantly associated with female group (P=0.01).
Because of the prevalence of vitamin D deficiency, identification of effective factors on vitamin D deficiency and also its impact on the incidence of allergic diseases, it seems necessary to study vitamin D deficiency and how to prevent it.