Elevated Serum Interleukin-23 and Interleukin-6 Levels in Schizophrenic Patients Compared to Those in Healthy Controls
Author(s):
Abstract:
Background
Various factors, including genetic, psychological, environmental, and immune dysfunction, may contribute to susceptibility to schizophrenia. Due to several reports regarding abnormal cytokine production, abnormal cytokine concentrations and their receptors in peripheral blood and cerebrospinal fluid, activation of the inflammatory response system, and altered levels of different cytokines in acute schizophrenia have been studied in recent years..Objectives
The purpose of this study was to examine interleukin-6 (IL-6) and IL-23 levels in schizophrenic patients versus those of healthy controls..Patients and
Methods
In this casecontrol study, serum levels of IL-6 and IL-23 of 30 schizophrenic patients and 20 age- and gender-matched healthy controls were measured using an enzyme-linked immunosorbent assay (ELISA). The serum levels of these cytokines were measured in schizophrenic patients experiencing their first episode who had not taken any psychotic drugs for at least 2 months prior to the study. Statistical analysis was performed using SPSS software, version 17. IL levels showed a non-Gaussian distribution. The statistical analysis was performed using appropriate statistical tests, including the Kruskal-Wallis or MannWhitney test..Results
Serum IL-23 levels of schizophrenic patients were significantly higher (696 ± 132 pg/mL) than those of the control subjects (313 ± 33 pg/mL) (P = 0.007). Serum IL-6 levels of the schizophrenic patients were also significantly higher than those of the controls (5.28 ± 1.1 and 2.54 ± 0.32 pg/mL, respectively; P = 0.01)..Conclusions
These findings indicate that immune system activation might be involved in the pathophysiology of schizophrenia..Keywords:
Schizophrenia , Immune System , Interleukin , 6 , Interleukin , 23
Language:
English
Published:
Shiraz Emedical Journal, Volume:17 Issue: 6, Jun 2016
Page:
1
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