Effects of Passion Flower Extract, as an Add-on Treatment to Sertraline, on Reaction Time in Patients ‎with Generalized Anxiety Disorder: a Double-blind Placebo-Controlled Study
Abstract:
Objective
Because of functional impairment caused by generalized anxiety disorder and due to cognitive side ýeffects of many anti-anxiety agents, in this study we aimed to evaluate the influence of Passion ýflower standardized extract on reaction time in patients with generalized anxiety disorder.ý
Method
Thirty patients aged 18 to 50 years of age, who were diagnosed with generalized anxiety disorder and ýfulfilled the study criteria, entered this double-blind placebo-controlled study. Reaction time was ýmeasured at baseline and after one month of treatment using computerized software. Correct ýresponses, omission and substitution errors and the mean time of correct responses (reaction time) in ýboth visual and auditory tests were collected. The analysis was performed between the two groups ýand within each group utilizing SPSS PASW- statics, Version 18. P-value less than 0.05 was ýconsidered statistically significant.ý
Results
All the participants were initiated on Sertraline 50 mg/day, and the dosage was increased to 100 ýmg / day after two weeks. Fourteen patients received Pasipy (Passion Flower) 15 drops three times ýdaily and 16 received placebo concurrently. Inter-group comparison proved no significant difference ýin any of the test items between assortments while a significant decline was observed in auditory ýomission errors in passion flower group after on month of treatment using intra-group analysis.ýý
Conclusion
This study noted that passion flower might be suitable as an add-on in the treatment of generalized ýanxiety disorder with low side effects. Further studies with longer duration are recommended to ýconfirm the results of this study.ý
Language:
English
Published:
Iranian Journal of Psychiatry, Volume:11 Issue: 3, Summer 2016
Pages:
191 to 197
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