Evaluation of the Effect of Two Different Systemic Doses of Viola Odorata on Prevention of Induced Tongue Dysplasia in Rats
Message:
Abstract:
Statement of the Problem: Oral cancer is among the ten most common cancers worldwide. It affects the life quality of patients in many ways.
Purpose
The aim of this study was to compare the effects of two different systemic doses of Viola Odorata syrup on the prevention of 4-Nitroquinoline-1-oxide (4-NQO) induced tongue dysplasia in rats.
Materials And Method
Forty-eight male Wistar rats were divided into four groups of A, B, C and D. Group A served as the control group. The rats in groups B to D received 30 ppm of 4-NQO in drinking water for 12 weeks. Additionally, the rats in groups B and C received Viola Odorata syrup at doses of 15 and 5 ml/kg, respectively, 3 times a week. Body weights were measured three times a week. At the end, the rats were euthanized and the tongue was removed. Histological evaluations for carcinogenesis were carried out under a light microscope.
Results
The mean body weight of the rats in groups B, C, and D were lower than that in group A (p
Conclusion
Viola Odorata extract has dose-dependent inhibitory effects on the development of tongue induced dysplasia.
Language:
English
Published:
Journal of Dentistry, Shiraz University of Medical Sciences, Volume:17 Issue: 3, Sep 2016
Pages:
185 to 192
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