The Effects of Methamphetamine on the Development of the Testes in Immature Male Rats

Methamphetamine (MAMP) is a central nervous system stimulant that its consumption has increased among youths. Adolescence is considered as a critical period and the reproductive organs are developing is very sensitive so that the. In this study, the effects of methamphetamine on the development of the testes in immature male rats were evaluated.
40 immature male Wistar Rats (35-day-old male rats) were divided into four groups: control and the group receiving methamphetamine: (1, 3, 5 mg/kg). The control group received saline and experimental groups received methamphetamine for 10 days (intraperitoneally) and they were allowed to mature. Then, the rats were dissected. Testicularb tissue was isolated and after weighing, they were prepared to be placed in formalin. The results were analyzed by ANOVA and Duncan's test.
Spaces created in the seminiferous tubules showed spermatogenesis disorder. The mean number of cells (spermatogonia, spermatocyte, spermatid, sperm) in the experimental groups decreased significantly than the control group (p Frequent consumption of methamphetamine, even in low doses through the influence on the pituitary -gonad and the various factors involved in spermatogenesis, can disrupt the sexual maturation, which may cause reduced fertility in males.