Evaluation of the Antinociceptive Effect of Hydroalcoholic Extract of Potentilla Reptans L. in the Adult Male Rat

Medicinal plants have been a focus of attention to researchers due to their fewer side effects in treating diseases comared to chemical drugs. Some health properties of medicinal plants such as anti-hypercholesterolemia and antioxidant effects of Potentilla reptans have been proven. Therefore, the present study aimed to investigate the antinociceptive and analgesic effect of hydro-alcoholic extract of Potentilla reptans L. (HEP) in the male rat.
In this experimental study, 36 male rats were divided into 6 groups, including: control group (normal saline), morphine group (1mg/kg), HEP groups (treated with 25, 50 and 100 mg/kg), and naloxone group (200 mg/kg). Writhing, formalin and tail-flick tests were used to evaluate the analgesic effects of the extract. In order to analyze the study data, variance and Tukey test were applied.
The results of the present study demonstrated that in writhing test (P The findings of the current study revealed that Potentilla reptans L. (HEP) has a significant analgesic effect. Opioid pathway seems to be one of the possible mechanisms of extract effects, which further clinical trials are recommended in this case.