Investigation of methanolic extract of Hypericum scabrum L. in the treatment of diabetes and liver enzyme activity in rats

Diabetes mellitus is an interference metabolism syndrome of carbohydrates, fat and proteins which can create as a result of shortage or absence of insulin or decreasing of tissues sensitivity regard to insulin. In this investigation the effect of methanolic extract of hypericum scabrum on the diabet and diabetic inflammation has been studied.as sample of 30 male wistar rats (200±20gr) were divided in to 5 groups. (n=6 in each group). 3 groups of rats gavaged with dose of 50, 80 and 110 mg/kg of methanolic extract of hypericum scabrum and controls remained intact. Check input items include food and water intake, blood sugar, liver enzymes (SGPT, SGOT) and LDL. The streptoztosin-diabetic rats were used. Results were analysed by one way analysis of varianc (ANOVA). The results of this research indicate that using the methanolic extract could effectively prevent of diabetes mellitus in rats. The sample wich received extract with 80 mg/kg dosage of their weight significantly decrease the liver enzymes activity in their bloods, their food and water usage was reduced and their blood sugar was declined. In attention to this topic that herbal drugs, with more research on clinical effects. This plant can be used as an appropriate replace for chemical drugs.