Evaluating the Most Common Mutation in BRCAI and BRCA2 Genes in Women Who had Mothers with Brest Cancer and Controls
Author(s):
Abstract:
Background and
Purpose
Breast Cancer is one of the health problems in every population. The aim of this study was to determine the frequency of BRCA1 and BRCA2 common mutations in women whose mothers were diagnosed with breast cancer.Materials And Methods
A casecontrol study was performed in 109 females (less than 40 years of age) who had mothers with breast cancer. For scanning of genomic mutations in BRCA1 and BRCA2, genes mutation analysis was done in BRCA1 (exon2, 20) and BRCA2 (exon11) using Real Time PCR test. We also studied 109 healthy controls without family history of breast cancer.Results
No any mutation was found in this population.Conclusion
This study showed no mutation in affected and control group. Therefore, other mutations and genes may have a role in breast cancer pathogenesis in our population.Keywords:
Language:
Persian
Published:
Journal of Mazandaran University of Medical Sciences, Volume:26 Issue: 141, 2016
Pages:
137 to 142
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