The effect of acrylic resins containing nanochitosan particles on the formation of Candida species biofilms isolated from the mouths of Subjects

Background and In people with denture, the growth of different candida species under the prosthesis leads to the formation of biofilm. This biofilm can play the role of a reservoir for candida and other kinds of microbes. Since Chitosan nanoparticles can cause long lasting antimicrobial activity, a more recent approach utilizes acrylic with nanochitosan particles is proposed. Therefore, we decided to study the inhibitory effect of nanochitosan particles in the biofilm formation of candida species in acrylic resins.
In this analytical laboratory study, suspensions of candida cells taken from the mouth of people with acrylic resins. were measured and compared to concentration of 0, 1%, 5% and 10% of adjacent nanochitosan particles and the amount of the formation of their biofilms on resins. In the end the data was analyzed using Kruskal-Wallis and chi-square tests .
The observed differences of biofilm formation in acrylic control resin and acrylic resins with nanochitosan particles was significant and meaningful ( P value In light of this research it is advised that dentures holders use acrylic nanoparticles, particularly for those who are hygienically weak and are ready for infection.