Comparing perioperative anxiolytic and analgesic effects of clonidine and midazolam in pediatric patients

0T In about 50% of cases, 0TChildren undergoing surgery receive premedication and midazolam is the most frequently used drug. Although midazolam is used for its preoperative anxiolytic effect in pediatrics; it is far from an ideal premedication, especially due to its effect on cognition including amnesia, confusion and emergence agitation. Clonidine lacks the majority of the side effects associated with midazolam and is associated with a number of beneficial perioperative effects.0T 0T
To compare perioperative anxiolytic and analgesic effects of clonidine and midazolam in pediatric patients.
Aterials and Total 50 pediatric patients’ candidate for elective surgery between 1-12 year ages were enrolled in the study and randomly assigned to one of two groups of study. Group M received 0.5 mg/kg Midazolam plus 0.02 mg/kg Atropine, and in group C, 0.004 mg/kg Clonidine plus 0.02 mg/kg Atropine was administered 1 hour prior to surgery. The Preoperative anxiety and postoperative pain and agitation were compared between two groups of study.
Age and sex was not significantly different between two groups of study. There were no significant differences between two groups of study in drug acceptance (p=0.447), separation anxiety (0.54), mask ventilation acceptance (p=0.051), sedation level at the time of induction of anesthesia (p=0.77). However emergence agitation (p=0.007) and postoperative pain score (p=0.001) was significantly lower in clonidine group compare to midazolam group.
Premedication with clonidine improves perioperative management of pediatric patients in compare to Midazolam in both inpatient and outpatient settings.