The effect of aerobic exercise training on circulating levels of adipsin and insulin resistance

A strong relationship between metabolic syndrome and type 2 diabetes has been reported. Since it is recently suggested that a possible role of adipsin in metabolic disorders; therefore, the objective of this study was to investigate the effect of aerobic exercise training on circulating levels of adipsin and insulin resistance in obese women with type 2 diabetes.
Subjects and Twenty-four obese women with type 2 diabetes (mean ± SD; age 41.3 ± 1.4 years and BMI 33.4 ± 2.3 kg/m2) participated in the study. They were randomly divided into two groups: Aerobic (n=12; age: 46.52±3.68 yr, BMI: 32.24±2.26) and control (n=12; age:45.82±6.79 yr, BMI:32.46± 3.28). Aerobic exercises were conducted for 8 weeks/ 3 sessions per week with intensity 12-15 from Borg Index. Blood samples before and after exercise were collected 24 hours before starting the protocol and after the last session of the exercise training. For data analysis paired-samples and independent T-test were used to compare mean differences each group’s pretest and posttest and between groups at the significance level of P ≤0.05.
There were significant decrease in fasting blood glocuse (P= 0.02), HOMA-IR (P=0.025), BMI (0.006), and body fat% levels (P= 0.005), although there were not significant changes in insulin (P= 0.358) and Adipsin (P= 0.777) of the experimental group.
According to the present results, we can conclude that aerobic exercise such as Pilates trainings is a suitable method to control diabetes in obese patients with type 2 diabetes.