side bias as an index for learning and memory ability in Morris water maze

In this study, relation between spatial learning ability in Morris Water Maze (MWM) and rotational-bias of male and female rats has been studied. Spatial learning ability of 54 male and female rats was evaluated in MWM and the relationship between spatial learning ability and rotational-bias of animal in MWM has been considered. Spatial learning ability in left side rotating male rats was better than those rotating to the right. However, in females, spatial learning ability in right rotating and retrieval of memory in left rotating animals were better. Comparing side-bias in male and female rats showed that spatial learning ability in right rotating and retrieval of memory in left rotating female rats were better than males. Our results showed that spatial learning ability in MWM could be anticipated by knowing the rotational bias of male or female rats in MWM. Considering this variable could help us to better explain the gender differences in the Morris water maze.