The effects of hydro-ethanolic extract of Arctium lappa leaves on wound healing

Wound healing is a complex process and studies show that many natural products such as herbal drugs have important effects on modulating of this process. Pharmacological studies indicated that Arctium lappa have anti-inflammatory, antimicrobial and anti-proliferative activities. The aim of this study was to evaluate the effects of Arctium lappa extract on wound healing process. Excision wound model was created in Wistar rats. The animals divided into three groups (n=6): control, vehicle and treatment group. Wound size, Number of inflammatory cells, collagen deposition and scar tissue area were studied. Number of inflammatory cells, statically were analyzed by one-way ANOVA followed by the Tukey’s post hoc test. Results show that number of inflammatory cells were significantly decreased in treated group compared to control and vehicle groups. Scar tissue reduced in treated groups and collagen deposition significantly increased in extract treated groups. Our study demonstrates that Arctium lappa have beneficial effects on healing of excision wound model.