Curcumin Protects Mice Testicular Tissue against the Adverse Effects of Sodium Arsenite: A Stereological Study

Sodium arsenite¡ an environmental pollutant¡ produces free radicals with harmful effects on the reproductive system. The aim of this study was to investigate the effect of curcumin¡ as a strong antioxidant¡ on the testis tissue and spermatogenic cell population in mice treated with sodium arsenite.
In this experimental study¡ Adult male NMRI mice were randomly divided into the 5 groups (n=6): control¡ sodium arsenite (5mg/kg/day)¡ curcumin (15mg/kg/day)¡ sodium arsenite狪�梧 and DMSO as vehicle. After 5 weeks of treatment (through intraperitoneal ingection)¡ animals right testis were removed¡ fixed¡ sectioned¡ stained (using heiden hain azan method) and stereologically studied. Data were analyzed using one-way ANOVA and Tuckey''s test and the means were considered significantly different at p A significant decrease in the mean volume (P Curcumin can compensate the harmful effects of sodium arsenite on the testicular tissue and spermatogenic cell populations in adult mice. Therefor¡ it is suggested as a supplement in the case of arsenite intoxication.