Effects of Sodium Nitrite on Liver Enzymes and Histological Structure of Liver in Streptozotocin-induced Diabetic Rats
Abstract:
Background and
Purpose
Nitrite is used for preserving food, especially in processed meat products. Processed foods containing nitrite are highly used in many countries. This harmful substances in water, soil and ecosystem endanger the health of people. In this study, we examined the effect of sodium nitrite on liver enzymes and histological structure of the liver in streptozotocin-induced diabetic rats.
Materials And Methods
In this study, 60 adult male Wistar rats were divided into six groups (n= 10 per group): a control group, experimental groups receiving 175 and 350 mg/kg/day sodium nitrite, a diabetic control group, and diabetic groups receiving 175 and 350 mg/kg/day sodium nitrite for 60 days. Diabetes was induced in rats by intraperitoneal administration of streptozotocin (65 mg/kg). Blood samples were collected after anesthesia and the serum AST, ALP, and ALT were measured. Also, liver tissues were removed to investigate the histological changes. Statistical analysis was done by one way variation and student’s ANOVA Test. P values less than 0.05 were considered significant.
Results
The AST, ALP, and ALT levels significantly increased in diabetic groups and the group receiving 175 and 350 mg/kg sodium nitrite (P
Conclusion
The results showed that sodium nitrite can induce adverse effects on the liver, especially on the liver in diabetic rats.
Language:
Persian
Published:
Journal of Mazandaran University of Medical Sciences, Volume:26 Issue: 144, 2017
Pages:
171 to 179
magiran.com/p1638318  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!