Serum Level and rs1800799 Polymorphism of MGP Gene Promoter in Patients with Coronary Arteries Stenosis

Background and Coronary artery stenosis is a progressive process associated with artery calcification. Although the role of matrix Gla protein (MGP) is not completely clear but its expression in vascular smooth muscle cells (VSMCs) and sub-endothelial macrophages suggests a role in vascular calcification. The rs1800799 is one of the polymorphisms oriented within transcription factor elements in the promoter region of the MGP gene that may modify MGP expression patterns resulting in artery calcification. In this study, we examined the serum level and rs1800799 polymorphism of MGP gene promoter in patients with stenosis of coronary artery in Tehran.
One hundred sixty three individuals undergoing coronary angiography were divided into two groups: patients (n=100) and controls (n=63). The lipid profile, serum MGP concentration and rs1800799 genotypes were measured by routine laboratory, ELIZA, and RFLP-PCR assays, respectively.
In this study, we observed positive relationships between the two groups in LDL, total cholesterol, and TG levels (P 0.05). Also, genotype and allele distributions did not differ significantly between the cases and controls (P> 0.05). Furthermore, the serum levels of MGP were not significantly different between genotypes (P> 0.1).
In this study, the rs1800799 genotype distribution and serum MGP value were not significantly associated with coronary heart disease. Moreover, the serum MGP level showed no major role in the progression of coronary artery stenosis.