Retinal Toxicity in Patients Treated with Hydroxychloroquine: A Cross-Section Study

Hydroxychloroquine (HCQ) is the commonly used antimalarial medicationfor the treatment of autoimmune diseases. It can produce irreversible retinal changes in vision. The aim of this study was evaluate the frequency of toxicity of HCQ and associated risk factors in Iranian patients.
A cross-sectional clinicalstudy was doneon 59 patients treated with HCQ during 2014-2015. Characteristics of Patient collected using questionnaire in two Part. Part one included basic characteristics of subjects (e.g. age, sex, family history, past medical history and demographic information) and ophthalmologic history included past ophthalmic history, cumulative dose and duration of using of HQ. For each patient, ophthalmology examinations include visual acuity (VA) with a Snellen chart at 6 meters in both eyes and abiomicroscopic examinationof the fundus under dilation, color vision exam, visual field testing within automated perimetry during 10 central degrees by sita-standard strategy was performed. Statistical significance differences was considered at the level of P