Investigation the effects of silver nano particles on ovary tissue and HPG axis in rats

Aim and By attention to extensive use of Silver nanoparticles, this study has been done to investigate the effects of silver these particles on ovary tissue and HPG axis.
Adult female rats were divided into five groups. Treatment groups received 25, 50, 100, and 200 mg/kg/day silver nano particles for 30 days orally. Then the rats weighed and levels of FSH, LH, estrogen, and progesterone were measured. Ovaries sections were studied using light microscopy.
The weight of rats and their ovaries, the level of FSH, LH, and Estrogen of serum decreased significantly in 50,100, and 200 mg/kg doses in comparison with the control (pResults have indicated poisonous effects of silver nanoparticles on HPG-axis and ovary tissue that is dose dependent. Therefore, enough precaution must be down in chronic exposure of females.