Effect of Kombucha Tea on Depression and Motor Activity in Mice

Depression is a threatening disease. Due to adverse effects of chemical antidepressant drugs, researcher’s attention has been shifted toward natural drug.
In this work, the antidepressant effect of Kombucha tea (KT) evaluated against reserpine induced depression in mice.
In this experimental study, 42 male mice were randomly divided into 6 groups of 7 mice. Vehicle mice received normal saline (1 mg/kg, i.p.), negative and positive control groups received reserpine (5mg/kg, i.p.) and fluoxetine (20 mg/kg, i.p.) respectively and treatment groups received Kombucha tea at doses of 250, 500, 1000 mg/kg, 18 h after administration of reserpine. Mice were then tested with forced swimming and rotarod tests. At the end of behavioral tests, blood sample were collected and used to assess blood antioxidant capacity.
There was significant difference in the duration of immobility time between vehicle and reserpine treated groups (P These results provide support for the potential antidepressant effects of Kombucha tea against.