Evaluation of the effect of premedication on pain severity and hemodynamic status of patients undergoing coronary angiography

As a stressful invasive procedure, angiography causes pain and several hemodynamic changes in patients. Various forms of premedication are used to reduce these complications; however, there is no consensus on their effectiveness. This study aimed to determine the effect of premedication on pain severity and hemodynamic status of patients undergoing coronary artery angiography.
Materials and Method This clinical trial was conducted on candidates for coronary angiography, who referred to Ganjavian Hospital of Dezful, Iran in 2012. In total, 102 patients were selected through convenience sampling and randomly divided into three groups of 34 cases. The first group was intravenously administered with four mg of chlorpheniramine, whereas the second and third groups were intravenously injected with five mg of diazepam and two mg of normal saline, respectively, 30 minutes before the angiography. Pain intensity and hemodynamic status of the patients were evaluated and recorded before, during and after the angiography. Data collection was carried out using visual analogue scale and hemodynamic status registration form. Data analysis was performed in SPSS version 19 using Chi-square, one-way analysis of variance, Friedman, Kruskal-Wallis and repeated measures analysis.
In this study, pain increased in all three groups after angiography (P According to the results of this study, no significant difference was observed between the groups in terms of the effect of different types of premedication on pain severity and hemodynamic status. It is recommended that the effect of premedication during other invasive procedures be also evaluated in further studies.