Short term effect of Fe2NiO4 nanoparticles on kidney function indeces in rat

Iron oxide nanoparticles, including nanoparticles is important in industry and medicine. Nanoparticles affect on detoxification of environmental pollutants such as Pesticides and chlorinated organic solvents.This study was done to evaluate the short term effect of Fe2NiO4 composite nanoparticle on kidney function indeces in wistar rats.
In this experimental study, Twenty four Wistar rat were randomly allocated into three groups, including: control, treated groups 1 and 2. Animales in control, treated groups 1 and 2 were received 0.5cc of saline, 0.5cc of solution containing 100, 200 ppm Fe2NiO4 for 7 days, respectively. Uric acid, ceratinine and urea (BUN) were measured at day 2, 7 and 14.
BUN level in treated groups 1 and 2 significantly reduced in comparison with control group at day 7, 14 after intervention (P It seems that the application of Fe2NiO4 nanoparticles in biological system has no toxic effect on the kidney function indeces.