Analgesic effect of chlorpheniramine in rat anaesthesia with acepromazine - ketamine combination

Recently, antihistamines is known as analgesic agents. The aim of the present study is to investigate the analgesic activity of chlorpheniramine (H1 antagonist), during anesthesia with acepromazine- ketamine combination and surgical operation in rat.
Methods & materials: 20 adult rats were randomly assigned in two groups. In first group, chlorpheniramine was administered and 30 minutes later acepromazine – Ketamine was injected. In second group, Normal saline was administerd initially and then acepromazine - Ketamine combination was injected. Assessment of pain reflexes was performed by toe pinch , tail pinch test and reflex of rats to laparotomy operation during anesthesia. Induction time of anesthesia, duration of light anesthesia, surgical anesthesia time, walking time, heart rate and respiratory rate was measured.
Time of light anesthesia in group 2 was shorter than group 1 (P chlorpheniramine as a premedication was induced appropriate balance anesthesia in rat with acepromazine- ketamine combination. Thus, chlorpheniramine could be used in rat as premedication agent for surgical operations in combined with acepromazine- ketamine.