THE EFFECT OF SWIMMING EXERCISE WITH INJECTIONS OF VITAMIN D SUPPLEMENTATION ON THE LEVELS OF NERVE GROWTH FACTOR (NGF) IN THE BRAIN TISSUE OF FEMALE RATS WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Abstract:
Background and Aims
This study aimed to determine the pretreatment effect of 6 week swimming exercise with injections of vitamin D supplementation on the levels of Nerve Growth Factor (NGF) in female Lewis rats.
Materials and Methods
This experimental in vitro study that was conducted on female Lewis rats. In this study, animals were randomly divided into 9 groups (n=5 per group), including sham, EAE control, vitamin D healthy, EAE vitamin D, healthy swimming, EAE swimming, EAE combination and healthy combination. Swimming training program included one hour daily for 6 weeks and 5 days a week. In addition, supplementary groups received vitamin D supplementation (2ng/0.2mg sesame oil/every two days) intraperitoneally for 2 weeks. NGF levels were measured by ELISA.
Results
The results of this study indicated that NGF levels in each group of EAE vitamin D and EAE swimming significantly increased compared with control group (respectively P= 0.049, P= 0.006). Also NGF levels in EAE combination group significantly increased compared with control group (p=0.004). Furthermore, the weight of EAE vitamin D group, EAE swimming training group and EAE combination group increased compared with control that these only in EAE vitamin D group were not significant (respectively P= 0.164, P=0.001, P= 0.016).
Conclusion
From the results it can be concluded the factors effective in neuroprotection are pretreatment with medium-term training, swimming and injection of vitamin D, and increasing the levels of NGF. Hence, it seems that swimming is a good way to enhance the protection of nerve cells in the brain against MS risk factors and promotion of brain health.
Language:
Persian
Published:
Journal of Medical Science Studies, Volume:28 Issue: 1, 2017
Page:
64
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